1 4 II 1 IV 2 3 (a) Ignoring the sibship in generation IV, what is the probability that both parents in the first- cousin mating are heterozygous? (b) Taking the sibship in generation IV into account, what is the probability that both parents in the first-cousin mating are heterozygous? %3D
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- i. Chands syndrome (OMIM 214350) is an autosornal recessive condition characterized by very ourly hair, underdeveloped nails, and abnormally shaped eyelids. In the following pedigree, which individuals must be carriers?All the non-shaded individuals are wild type apart from III.1. III.1 has been proven to have the causative mutation for this Autosomal Dominant condition, but they exhibit no symptoms.What is the percentage level of penetrance for the condition in the diagram?Could the pedigree in Figure 2-31 be explained as an autosomal dominant disorder? Explain.
- The accompanying pedigree shows a family in which one child (II-1) has an autosomal recessive condition. On the basis of this fact alone, provide the following information. 1) What is the chance that among the three children in generation II who have the dominant phenotype, one of them is AAAA and two of them are AaAa? (Hint: Consider all possible orders of genotypes.) Express your answer to two decimal places.Marfan syndrome (Section 13.5) is inherited in an autosomal dominant pattern. What is the chance that a child will inherit the associated allele if one parent does not carry it and the other is heterozygous?Ectrodactyly is a rare condition in which the fingers are absent, and the hand is split. It is usually inherited as an autosomal dominant trait. What do the double horizontal lines mean between III-1 and III-4? Is the pedigree below consistent with autosomal dominant inheritance?
- 70 T 꿈 ㅁ ㅁ 이어어어어어어 In the pedigree shown, indicate whether each of the following inheritance patterns is possible by selecting YES or NO from the appropriate drop down menu. Y-linked Autosomal Recessive Autosomal Dominant X-linked Recessive X-linked Dominant ()In 1995, doctors reported a Chinese family in whichretinitis pigmentosa (progressive degeneration of theretina leading to blindness) affected only males. Allsix sons of affected males were affected, but all of thefive daughters of affected males (and all of thechildren of these daughters) were unaffected.a. What is the likelihood that this form of retinitispigmentosa is due to an autosomal mutationshowing complete dominance?b. What other possibilities could explain the inheritance of retinitis pigmentosa in this family? Whichof these possibilities do you think is most likely?Please consider the following pedigree. Assume that people who marry in to the family do not carry the allele unless otherwise indicated. Assume complete penetrance. I II 5 6 III 6 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Provide a genotype for individual III-6 for the most likely mode of inheritance as determined in (a).
- Drosophila females of wild-type appearance but heterozygous for three autosomal genes are mated with malesshowing the three corresponding autosomal recessivetraits: glassy eyes, coal-colored bodies, and striped thoraxes. One thousand (1000) progeny of this cross aredistributed in the following phenotypic classes:Wild type 27Striped thorax 11Coal body 484Glassy eyes, coal body 8Glassy eyes, striped thorax 441Glassy eyes, coal body, striped thorax 29a. Draw a genetic map based on these data.b. Show the arrangement of alleles on the two homologous chromosomes in the parent females.c. Normal-appearing males containing the samechromosomes as the parent females in the precedingcross are mated with females showing glassy eyes,coal-colored bodies, and striped thoraxes. Of 1000progeny produced, indicate the numbers of thevarious phenotypic classes you would expect.A woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) What kind of chromosomal aberration is shown?Consider two hypothetical recessive autosomal genesa and b, where a heterozygote is testcrossed to a doublehomozygousmutant. Predict the phenotypic ratios underthe following conditions:(a) a and b are located on separate autosomes.(b) a and b are linked on the same autosome but areso far apart that a crossover always occurs betweenthem.(c) a and b are linked on the same autosome but are soclose together that a crossover almost never occurs