47. Tretinoin gel (RETIN-A MICRO) is avail- able in two strengths: 0.1% w/w and 0.04% w/w. Which of these represents equivalent concentrations of the two strengths? (a) 15 mg/15 g and 30 mg/30 g (b) 5 mg/5 g and 0.06 g/15 g (c) 15 mg/15 g and 60 mg/15 g (d) 30 mg/30 g and 6 mg/15 g 47. (d) 30 mg/30 g and 6 mg/15 g
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- Paclitaxel is used to treat ovarian cancer by infusion at a concentration of 0.6 mg/mL over 24 hours. A dose of 135 mg/m² has been prescribed for Sero. Sero is 1.06 m tall and weighs 92 kg. Paclitaxel comes in vials of 150 mg/25 mL. Calculate the volume of 5%w/v glucose solution that would be required to dilute the concentrated solution to prepare an paclitaxel solution of the required strength.Paclitaxel is used to treat ovarian cancer by infusion at a concentration of 0.6 mg/mL over 24 hours. A dose of 135 mg/m² has been prescribed for Sero. Sero is 1.06 m tall and weighs 92 kg. Paclitaxel comes in vials of 150 mg/25 mL. Calculate the volume of 5%w/v glucose solution that would be required to dilute the concentrated solution to prepare an paclitaxel solution of the required strength. Answer: You did not give the correct unit. The correct answer is: 333 mL X31. The formula for a cosmetic cream calls for 5% of an emulsifier blend consisting of Span 60 and Tween20. If the Required HLB of the oil phase is 14.0, how much of each of the emulsifiers, respectively, shouldbe used in preparing 500 grams of the cream? (HLB for Span 60 = 4.7; HLB for Tween 20 = 16.7)a. 5.6 grams; 19.4 gramsb. 8.4 grams; 16.6 gramsc. 12.5 grams; 12.5 gramsd. 15.2 grams; 9.8 grams
- Predict the diffusivity of human serum albumin at 293 K in water as a dilute solution and compare it with experimental data. Assume the following: The molecular weight of human serum albumin, MA= 72,300 kg/kmol The viscosity of water at 293 K is 0.897 x 10-3 Pa∙s The experimental data value is 5.93 x 10-11 m2/s.1. Lactoferrin is an iron-binding glycoprotein that forms the antibiotic fragment lactoferricin during digestion. The protein was isolated from 1.5 liters of ewe skim milk by successive ammonium sulfate precipitation until a final salt concentration of 70% was obtained. Determine the amount (in g) of powdered ammonium sulfate needed in bringing the solution from (a) 0% to 40% saturation and (b) 40% to 70% saturation assuming that the volume remains constant. Initial concentration of (NH4)2SO4, % saturation 0 10 20 30 40 50 60 70 80 90 10 55 Final concentration of (NH4)2SO4, % saturation 30 40 50 60 70 80 Grams of solid (NH4)2SO4 to be added to 1 L of solution 176 242 314 390 472 561 657 117 405 491 584 59 421 351 438 20 113 57 182 121 61 251 325 63 188 126 195 130 65 260 337 270 202 281 135 67 210 140 70 90 761 685 511 609 533 365 292 219 146 HUGH LATLE 100 73 457 381 305 228 152 7610 tab of acetaminophen 500 mg molar absorptivity= 14520 @ 243nm. The total weight of the 10tab is 5278 mg. I take a sample equivalent to 100mg of tablet and I diluted it in 100mL, I took an aliquot of 10mL and I diluted it in 250mL, of these I took 25mL and I diluted them in 250mL. Calculate the weight per tablet. Absorbance = 0.944
- 1. Draw an approximate titration curve for lysine, given that its pKa(COOH) = 2.18, its pKa(NH3*) = 8.95, and its pka(R) = 10.53. a. What pH ranges would Lys be a good buffer at? b. What is the pl of Lys? C. Draw the structures of the predominant species in solution at (i) pH 0, (ii) pH 7, (iii) pH 9.5, (iv) pH 12.In an experiment, separation of albumin from chicken liver was attempted at 31%, 58%, and 65% saturation with ammonium sulfate, (NH4)2SO4. After homogenization and centrifugation, 23 ml of the supernatant was obtained. What is the volume of saturated buffered (NH4)2SO4 (pH 7.0) that must be added to make the solution 31% saturated? 10.3 ml 8.33 ml 9.50 ml O 12.2 ml80mL of a 0.3M solution of hexapeptide Leu-His-Cys-Glu-Asn-Arg is adjusted to pH=pI. The solution is then titrated with 0.2M HCL to a final pH of 2.1. Sketch the titration curve, labelling the pH and volume axes. Indicate the volume of HCL needed to reach relevant pKa value and equivalence point(s)z Relevant pKa values are: 2.1, 4.3, 6.0, 8.3, 9.8, and 12.5.
- 4. A solution containing egg albumin (pl-4.6), B-lactoglobulin (pl-5.2), and chymotrypsinogen (pl=9.5) was loaded onto a column of diethylaminoethyl cellulose (DEAE-cellulose) at pH 5.4.The column was then eluted with a pH 5.4 buffer, with an increasing salt concentration. Predict the elution pattern.Solution Absorbance mg/ml aspirin Standard solution - 1.6 mg/mL A 0.638 0.08 mg/mL B 0.504 0.064 mg/mL C 0.376 0.048 mg/mL D 0.259 0.032 mg/mL E 0.126 0.016 mg/mL A = -log T where T = %T ÷ 100 Construct a callibration curve using the above data. Absorbance should be on the vertical axis and "mg/mL of acetylsalicylic acid" on the horizontal axis. The line should go through the origin. Using the data provided, the graph you have generated, and the procedure that was used to generate the solutions which were examined by spectroscopy, calculate the amount of acetylsalicylic acid per tablet. Commercial tablet 1 labelled as 100 mg enteric coated Absorbance = 0.16 Commercial tablet 2 labelled as 300 mg Absorbance = 0.45 Student prepared tablet from practical 5 Absorbance = 0.19 Using the data provided, the graph you have generated, and the procedure that was used…26. If 100 mL of a solution for patient-con- trolled anesthesia contains 200 mg of morphine sulfate and 8 mg of droperidol, calculate the percentage strength of each of these ingredients in the solution. 26. 0.2% w/v morphine sulfate and 0.008% w/v droperidol