A dominantly inherited genetic disease is identified over several generations of a large family. However, about half the families have dominant disease with complete pen- etrance, whereby if a parent is affected there is a 50% probability that any one offspring will be affected. Similarly, about half the families have dominant disease with reduced penetrance, whereby if a parent is affected there is a 25% probability that any one offspring will be affected. Suppose in a particular family one parent and two of the two offspring are affected. What is the probability that exactly two of the two offspring will be affected in a family with dominant disease with complete penetrance? What is the probability that exactly two of the two offspring will be affected in a family with dominant disease with complete penetrance? What is the probability that exactly two of the two offspring will be affected in a family with dominant disease with reduced penetrance? What is the probability that the mode of transmission for this particular family is dominant with complete penetrance? Is this a prior probability or a posterior probability?
Contingency Table
A contingency table can be defined as the visual representation of the relationship between two or more categorical variables that can be evaluated and registered. It is a categorical version of the scatterplot, which is used to investigate the linear relationship between two variables. A contingency table is indeed a type of frequency distribution table that displays two variables at the same time.
Binomial Distribution
Binomial is an algebraic expression of the sum or the difference of two terms. Before knowing about binomial distribution, we must know about the binomial theorem.
A dominantly inherited genetic disease is identified over several generations of a large family. However, about half the families have dominant disease with complete pen-
etrance, whereby if a parent is affected there is a 50%
penetrance, whereby if a parent is affected there is a 25% probability that any one offspring will be affected. Suppose in a particular family one parent and two of the two
offspring are affected.
What is the probability that exactly two of the two offspring will be affected in a family with dominant disease with complete penetrance?
What is the probability that exactly two of the two offspring will be affected in a family with dominant disease with complete penetrance?
What is the probability that exactly two of the two offspring will be affected in a family with dominant disease with reduced penetrance?
What is the probability that the
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