Assume that a sibling sought your advice as a Proband. Acting as a genetic counselor for your own family, complete the following: Scenario: Your Grandmother has a diabetes and the oldest brother of your mother is diabetic. Create a pedigree tree that will show the inheritance pattern of a specific trait in at least 4 generations of your own family. Follow standard rules and symbols in constructing the pedigree. Analyze the inheritance mechanism behind the trait, and address possible concerns that

Assume that a sibling sought your advice as a Proband. Acting as a genetic counselor for your own family, complete the following: Scenario: Your Grandmother has a diabetes and the oldest brother of your mother is diabetic. Create a pedigree tree that will show the inheritance pattern of a specific trait in at least 4 generations of your own family. Follow standard rules and symbols in constructing the pedigree. Analyze the inheritance mechanism behind the trait, and address possible concerns that

Name: Pedigree AnalysisAssume that a sibling sought your advice as a Proband
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Description: Pedigree AnalysisAssume that a sibling sought your advice as a Proband. Acting as a genetic counselor for your own family, complete the following: Scenario: Your Grandmother has a diabetes and the oldest brother of your mother is diabetic.Create a pe

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter4: Pedigree Analysis In Human Genetics

Section: Chapter Questions

Problem 10QP: A proband female with an unidentified disease seeks the advice of a genetic counselor before...

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Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?
Pedigree Analysis Is a Basic Method in Human Genetics Using the pedigree provided, answer the following questions. a. Is the proband male or female? b. Is the grandfather of the proband affected? c. How many siblings does the proband have, and where is he or she in the birth order?
Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?
Consider the following pedigree. Solid symbols represent individuals affected by the trait. Assume complete penetrance and non-variable expressivity. II 3 4 III 1 2 3 5 6 a) what is the mode of inheritance of this trait? b) Does the ratio of affected to unaffected offspring in generation III-1 to 1II-4 match the expected ratio for this mode of inheritance? Explain your answer in terms of the expected ratio versus the ratio observed. Give a reason for your answer. No mark is assigned for yes or no)
Help me create a pedigree of this information: Pedigree analysis: Generation 1: Normal parents (AA x AA) Generation 2: Carrier parents (AA x AS) Generation 3: Affected child (AS x AS) Generation 4: Affected grandchild (SS) This pedigree has two normal parents in the first generation. Second generation carriers carry the sickle cell trait from one parent. The disease is 25% more likely to be inherited in the third generation if both parents have the 'S' allele. If both parents have the 'S' allele, their children will have sickle cell anemia in the fourth generation
A. Identify the pattern of inheritance in the pedigree below. B. Provide two pieces of evidence that you used to come to this conclusion. C. Identify the genotypes of individuals II-1 and III-2 (at the arrows)
A proband female with an unidentified disease seeks the advice of a genetic counselor before starting a family. Based on the following data, the counselor constructs a pedigree encompassing three generations: (1) The maternal grandfather of the proband has the disease. (2) The mother of the proband is unaffected and is the youngest of five children, the three oldest being male. (3) The proband has an affected older sister, but the youngest siblings are unaffected twins (boy and girl). (4) All the individuals who have the disease have been revealed. Duplicate the counselors feat
One family is shown in both pedigrees below. Each pedigree focuses on a different monogenic, fully penetrant phenotype. Shaded individuals affected by Phenotype 1: 3 Shaded individuals affected by Phenotype 2: a. Phenotype 1: Which modes of inheritance can be ruled out, base don't this pedigree? For each mode of inheritance listed below, either state that it is not ruled out, or describe a detail of the pedigree that allows you to rule it out. Autosomal recessive Autosomal dominant X-linked recessive X-linked dominant Y-linked b. Phenotype 2: Which modes of inheritance can be ruled out, base don't this pedigree? For each mode of inheritance listed below, either state that it is not ruled out, or describe a detail of the pedigree that allows you to rule it out. Autosomal recessive Autosomal dominant X-linked recessive X-linked dominant
The mini-pedigree below illustrates a pair of expectant parents. One of them is heterozygous for a dominant allele causing a fully penetrant, autosomal trait (filled square). The other is unaffected and lacks the dominant allele (open circle). The unborn child of this couple is represented by the diamond; the child's phenotype is not yet known. A SNP locus 10 map units from the gene determining this trait has 3 alleles: A, G and C; the genotype of each individual for this SNP is shown below their pedigree symbol. If the G allele of the SNP locus is on the same chromosome as the dominant trait allele in the affected parent, what is the probability that the child will eventually express the trait? AG 0% 90% 10% O 100% AC CC
Answer the following questions given the pedigree below. Please assume that no other mutations are occurring, complete penetrance, and that the individual marked with an asterisk (*) doesn’t carry the allele causing the affected phenotype. Q4) Assuming II-2 and II-3 want to have another child. what are all the possible genotypes, and what is the percentage that their child will be affected?
A genetic disorder is caused by a LOF mutation (Bm) and epigenetic imprinting of gene B. Through pedigree analysis of many families, researchers have observed the following results: Female carrier B+Bm x B+B+ --> B+Bm and Mother's genotype Father's genotype Children's genotype Children's phenotype Cross 1: B+Bm B+B+ B+Bm , B+B+ some affected, some unaffected Cross 2: B+B+ B+Bm B+Bm , B+B+ always unaffected Based on these results, gene B is imprinted on the: a. maternal b. paternal
A. Identify the most likely inheritance pattern in the pedigree below. B. What are the genotypes of individuals II-2 and III-2? Use any letter for your example. 1 4 II 1 2 3 4 5 6 7 II 2 3 4 5 6 7 9 10 11 IV 1 2 3 6 7 8 2. 4,