Choose the False statement regarding mechanism of protease? 1. Cysteine proteases perform covalent catalysis, using third group of cysteine as a nucleophile. 2. Serine, threonine, and cysteine proteases all perform covalent catalysis. 3. Metalloproteases and aspartate proteases perform noncovalent catalysis. 4. HIV-1 protease is an aspartate protease and a target of anti-HIV therapies. 5. In metalloproteases, a metal ion cofactor changes the state of oxidation.
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- Draw the mechanism of action of an HIV protease. Label the substrate, the intermediates, and the products. Indicate each type of catalysis that occurs throughout the mechanism..Which of the following enzymes requires a cofactor to carry out catalysis? A- GI lipase B- HIV protease C- Aldehyde dehydrogenase D- Epoxide hydrolase E- Beta-LactamaseProteases are one of the main drug targets. Choose the False statement regarding proteases. A. Proteases are enzymes that cleave peptide bonds. B. Water is a reactant in the reaction catalyzed by proteases. C. Proteases, like all enzymes show substrate specificity, meaning they cleave only substate that fit the bonding product. D. Proteases rely on the proton transfer from NADH to the substrate. E. Protease mechanism involves only acid-base catalysis.
- A. AG for the two reactions is different B. Trypsin is a protein, and elastase is not D. One of the reactions is endergonic, and the other is exergonic Hydrolysis of lysine bonds requires water; hydrolysis of alanine bonds des Part I: Microbiology 7. Which structures play direct roles in permitting bacteria to adhere to each other or to other surfaces? A. Cell wall and capsules B Capsule and fimbriae C. Cell membrane and endospores D. None 8. If E. coli lacks an F factor (F plasmid), and if bacteriophages are excluded from the bacterial cultures, then by which of these means Jilug some genes might be transmitted to other E. coli cells? A. via sex pili via transduction C. via conjugation D. via transformation both B and C 9. Broad-spectrum antibiotics inhibit the growth of most intestinal bacteria. A hospital patient who is Jas receiving broad-spectrum antibiotics is most likely to become A. unable to fix carbon dioxide B. unable to fix nitrogen deficient in certain vitamin K D. unable…Which of the following is false regarding Serine Proteases? O They employ general acid-base catalysis They contain a catalytic Triad of His, Ser, and Asp residues They employ metal ion catalysis O They cleave simple organic ester bonds near larger residuesPart A What kind of inhibition is imposed on HIV protease by ritonavir? O irreversible inhibition O reversible inhibition O uncompetitive inhibition. Submit Request Answer
- 19. Identify a FALSE statement from the following, Group of answer choices Clotrimazole inhibits cholesterol synthesis in fungal membrane Clotrimazole is used for treatment of superficial yeast infection Gresiofulvin is ideally used for nail and skin fungal treatment Polyenes forms pores in fungal membrane by disrupting ergosterol Gresiofulvin inhibits microtubules polymerization and depolymerization 20. Media used to isolate N. gonorrhea from clinical samples ................... Group of answer choices Anaerobic Growth Media Thayer Martin Media Sabouraud’s Media Blood Agar Media Differential MediaWhat is your personal comment on the relevance of this application? Refer to the study below https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824784/ Riboswitches as Drug Targets for Antibiotics Vipul Panchal* and Ruth Brenk*Whether an antimicrobial is broad spectrum or narrow spectrum depends on its mode of action. For the following 2 hypothetical drugs, predict whether they are broad spectrum or narrow spectrum. Explain your reasoning: 4. a. Drug A interferes with peptidoglycan synthesis - b. Drug B interferes with 70S ribosome function- c. Drug C interferes with synthesis of a vitamin –
- Given the active site diagram below, which best described the mechanism(s) of Active Site `NH2. SH OH - catalysis? NH -Mg²+ O Acid-Base O Acid-Base & Metal lon Covalent Catalysis Acid-Base & Covalent Catalysis O Metal lonMatch the following drug targets with the type of antibiotic that uses them (answers may be used more than once or not at all). a. Cell wall b.Cell membrane c. Protein synthesis (Transcription/Translation) d. Metabolic Pathway e. Nucleic Acid synthesis Chloramphenicol Clindamycin Erythromycin Doxycycline Sulfonamides Answer these multiple-choice questions as well. Please give just the answer and no explanation. 1. Which is not true of virus capsids?a. They surround and protect viral nucleic acidb. Always icosahedral in shapec. Remain outside of host bacterial cells while the nucleic acid is injected into the bacterial celld. Enters host animal cells together with the nucleic acid e. Made up of protein subunits called capsomeres 2. All viruses have: a. DNA b. RNAc. Envelopesd. Glycoprotein spikes e. Host specificity 3. Use the following to select the sequence of events during replication of DNA viruses in animal cells:1 = replication of viral nucleic acid2 = adsorption3…Choose the false statement: Penicillin is a ß lactam which inhibits bacterial growth by inhibiting DNA polymerase. O Resistance to ß lactamase inhibitors arises when bacteria duplicate the ß lactamase gene. O B lactamase inhibitors are prescribed together with antibiotics like penicillin in order to combat resistance to these antibiotics. Question 10 Choose the false statement below: OUsing multiple antimicrobials in combination is an ineffective strategy because they generally are redundant in effect and the chance of drug resistance will be increased. O Because of its complex structure and multiple binding sites, the ribosome is the target for multiple types of antibiotics. O Choice of an antimicrobial agent may be dependent upon the material treated as well as the susceptíbility of the microbe.