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Clinical case 2: -e An experimental drug was administered as an oral dose of 500 mg to nine patients with hypertenion. The following pharmacokinetic parameters were reported: Absorption rate constant = 2.10 h* yu/mL Elimination rate constant =0.110 h Apparent volume of distribution = 20 L Absolute bioavailability = 0.95. The maximum amount of this anti-hypertension drug desired in the body (minimum toxic amount) is 800 mg; while 15 mg/L is the minimum plasma concentration required for therapeutic effect (MEC). I/ka Xof OCka-k Calculate a regimen for 250 mg, 500 mg, and 75omg tablets of this drug.

Clinical case 2: -e An experimental drug was administered as an oral dose of 500 mg to nine patients with hypertenion. The following pharmacokinetic parameters were reported: Absorption rate constant = 2.10 h* yu/mL Elimination rate constant =0.110 h Apparent volume of distribution = 20 L Absolute bioavailability = 0.95. The maximum amount of this anti-hypertension drug desired in the body (minimum toxic amount) is 800 mg; while 15 mg/L is the minimum plasma concentration required for therapeutic effect (MEC). I/ka Xof OCka-k Calculate a regimen for 250 mg, 500 mg, and 75omg tablets of this drug.

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Clinical case 2: -e An experimental drug was administered as an oral dose of 500 mg to nine patients with hypertenion. The following pharmacokinetic parameters were reported: Absorption rate constant = 2.10 h* yu/mL Elimination rate constant =0.110 h Apparent volume of distribution = 20 L Absolute bioavailability = 0.95. The maximum amount of this anti-hypertension drug desired in the body (minimum toxic amount) is 800 mg; while 15 mg/L is the minimum plasma concentration required for therapeutic effect (MEC). I/ka Xof OCka-k Calculate a regimen for 250 mg, 500 mg, and 75omg tablets of this drug.
Transcribed Image Text:Clinical case 2: -e An experimental drug was administered as an oral dose of 500 mg to nine patients with hypertenion. The following pharmacokinetic parameters were reported: Absorption rate constant = 2.10 h* yu/mL Elimination rate constant =0.110 h Apparent volume of distribution = 20 L Absolute bioavailability = 0.95. The maximum amount of this anti-hypertension drug desired in the body (minimum toxic amount) is 800 mg; while 15 mg/L is the minimum plasma concentration required for therapeutic effect (MEC). I/ka Xof OCka-k Calculate a regimen for 250 mg, 500 mg, and 75omg tablets of this drug.
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