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How is it possible for the GABA activated chloride channel (GABA-A receptor) to switch the direction of ion flow during development? This occurs when the KCC2 transporter becomes active and transports chloride ions out of the cell to lower the chloride concentration inside the cell from 25mM to 4mM. Explain your answer using thermodynamic principles of ion flow through ion channels (passive diffusion while the channel is open). Hint: calculate deltaG (free energy change),   R=8.315 J/mol *K,   T=310K,   F=96,500 J/(V*mol),   membrane potential (delta psi) = -60mV (negative inside), Cl- concentration outside cell: 110mM

How is it possible for the GABA activated chloride channel (GABA-A receptor) to switch the direction of ion flow during development? This occurs when the KCC2 transporter becomes active and transports chloride ions out of the cell to lower the chloride concentration inside the cell from 25mM to 4mM. Explain your answer using thermodynamic principles of ion flow through ion channels (passive diffusion while the channel is open). Hint: calculate deltaG (free energy change),   R=8.315 J/mol *K,   T=310K,   F=96,500 J/(V*mol),   membrane potential (delta psi) = -60mV (negative inside), Cl- concentration outside cell: 110mM

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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How is it possible for the GABA activated chloride channel (GABA-A receptor) to switch the direction of ion flow during development? This occurs when the KCC2 transporter becomes active and transports chloride ions out of the cell to lower the chloride concentration inside the cell from 25mM to 4mM.

Explain your answer using thermodynamic principles of ion flow through ion channels (passive diffusion while the channel is open).

Hint: calculate deltaG (free energy change),   R=8.315 J/mol *K,   T=310K,   F=96,500 J/(V*mol),   membrane potential (delta psi) = -60mV (negative inside), Cl- concentration outside cell: 110mM  

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