Questions below true or false about the following statements on Drosophila eye development I am struggling with how to work through this... Hh, which is expressed by the developing photoreceptors in the anterior eye disc, induces cells in the morphogenetic furrow (MF) to express DPP, which is the ligand of DPP (BMP) signaling. Wg and Notch signaling inhibit while Hh and DPP signaling promote the co-expression of RD genes including Ey (Eyeless) and Eya (Eyes absent) in the preproneural (PPN) domain anterior to the MF. Co-expression of the retinal determination (RD) network genes Eya (Eyes absent), sine oculis (so), and Ey (Eyeless), which is observed in PPD domain of eye disc, are required for retinal determination and for induction of atonal expression. While EGFR signaling is not required for R8 specification, EGFR signaling is required for cell survival in posterior eye discs and for the differentiation of all the remaining cell types in the ommatidia. During Drosophila eye development, cell proliferation in the second mitotic wave is required for the differentiation of different cell types in ommatidia, such as photoreceptors, pigment cells and bristles. During eye development, Notch signaling play critical roles regulating cell proliferation in eye disc through inducing Eyegone expression.

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter9: Cell Communication

Section: Chapter Questions

Problem 9TYK

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Questions below true or false about the following statements on Drosophila eye development

I am struggling with how to work through this...

Hh, which is expressed by the developing photoreceptors in the anterior eye disc, induces cells in the morphogenetic furrow (MF) to express DPP, which is the ligand of DPP (BMP) signaling.

Wg and Notch signaling inhibit while Hh and DPP signaling promote the co-expression of RD genes including Ey (Eyeless) and Eya (Eyes absent) in the preproneural (PPN) domain anterior to the MF.

Co-expression of the retinal determination (RD) network genes Eya (Eyes absent), sine oculis (so), and Ey (Eyeless), which is observed in PPD domain of eye disc, are required for retinal determination and for induction of atonal expression.

While EGFR signaling is not required for R8 specification, EGFR signaling is required for cell survival in posterior eye discs and for the differentiation of all the remaining cell types in the ommatidia.

During Drosophila eye development, cell proliferation in the second mitotic wave is required for the differentiation of different cell types in ommatidia, such as photoreceptors, pigment cells and bristles.

During eye development, Notch signaling play critical roles regulating cell proliferation in eye disc through inducing Eyegone expression.

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