Which best describe the HIV REV protein? Code for proteins necessary for synthesis of the viral capsids. Code for proteins that is cleaved to produce reserve transcriptase. Binds a specific stem-loop structure in the viral RNAs into cytosol. None of the above.
Which best describe the HIV REV protein?
Code for proteins necessary for synthesis of the viral capsids.
Code for proteins that is cleaved to produce reserve transcriptase.
Binds a specific stem-loop structure in the viral RNAs into cytosol.
None of the above.
HIV REV Protein:
Rev is a transactivating protein required for HIV-1 (and other lentiviral) protein expression regulation. The rev gene encodes a nuclear localization signal that permits the Rev protein to be recruited to the nucleus, where it participates in the export of unspliced and incompletely spliced mRNAs. mRNAs of HIV-1 late (structural) genes are maintained in the nucleus in the absence of Rev, limiting translation.
Rev is a 116-amino-acid protein with a molecular weight of 13 kDa. Rev's sequence has two distinct domains that help it import and export nuclear material. In most cases, the protein functions as a tetramer.
Completely processed mRNA transcripts are used to translate HIV-1 regulatory proteins (including Rev), whereas incompletely spliced transcripts are used to translate structural proteins. Completely spliced transcripts, like cellular mRNA, are exported from the nucleus to the cytoplasm by the same method. However, Rev is required for the production of viral structural proteins from incompletely spliced mRNAs.
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