Which of the following statements concerning T cell development is correct? A. Progenitor T cells that enter the thymus from the bone marrow express CD4 or CD8 B. Interaction with thymic non-lymphoid cells is critical C. Maturation in the thymus requires the presence of foreign antigen D. MHC II molecules are not involved in positive selection

Which of the following statements concerning T cell development is correct? A. Progenitor T cells that enter the thymus from the bone marrow express CD4 or CD8 B. Interaction with thymic non-lymphoid cells is critical C. Maturation in the thymus requires the presence of foreign antigen D. MHC II molecules are not involved in positive selection

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter42: The Immune System

Section: Chapter Questions

Problem 1VCQ: Figure 42.11 Which of the following statements about T cells is false? Helper T cells release...

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Question:- Place these in the order in which they occur in the immune system. What order do these events relating to effector responses occur in? Activated B cells leave lymph nodes and move into bloodstream Activated B and T cells exit the blood stream at the site of infection Activated T cells leave lymph nodes and move into bloodstream Activated Tcytotoxic cells look for and kill infected self cells Antibodies bind directly to non-self microbes Antibodies help improve phagocytosis (‘opsonization’) Antibodies leak out of bloodstream at site of infection Antibodies secreted in lymph node travel through bloodstream Memory B and T cells patrol around the body looking to be activated by the same microbial substances that activated them in the first place.
Which of the following statements is correct about the development of T cells? O After many cell generations, some of the CD8+ T cells differentiate into at least six functional phenotypes. - T cells differentiate into progenitor cells destined to become (1) natural T regulatory (Treg) cells, (2) natural killer T (NKT) cells, (3) gamma/delta T cells, and (4) alpha/beta T cells. Activation by its specific antigen causes a T helper cell (TH) cell to mature into a cytotoxic T lymphocyte (CTL) that functions to destroy host cells that have been infected by intracellular pathogens, such as a virus, or have altered MHC surface proteins. T cells originate from CD34+ stem cells in the bone marrow, where they also mature.
Illustrate the development of T-cells and B-cells comparing the stages and steps in these two processes. Draw the two schematics side by side to align the comparative stages (progenitors to mature cells) and steps and point out the key common mechanisms and differences if any. This needs to be a labeled drawing please.
Match the term with its correct description. selection for thymocytes which recognize self MHC molecules elimination of thymocytes which recognize self continued alpha chain rearrangement until a functional TCR is generated process by which autoreactive thymocytes are eliminated in the thymus activation of a T-cell only if the appropriate MHC molecule presents an antigenic peptide ✓Choose... Apoptosis MHC restriction Positive selection Negative selection T-cell receptor editing Choose...
True or false: 1. Highly proliferative centroblasts are located in the light-zone rather than the dark zone of the germinal center 2. All memory cells (central memory, effector memory, tissue-resident) have equivalent tissue-homing capacity 3. Effector T cells home to sites of infection through action of tissue-specific chemokines. 4. The differentiation fate of CD4 T cells is pre-determined before activation.
Determine which statement(s) are true/false NK cells are a type of lymphocyte involved in acquired immunity Plasma cells are a type of B- cell that directly bind antigens on target cells ✓ [Choose ] False True Binding of antigen to the cell surface of B-memory cells is a trigger for the secondary immune response Loss of MHC Class I expression would decrease the effectiveness of cytotoxic T-cell response [Choose ] [Choose ] [Choose ] >
1. Which of the following statements about CD4+ Th17 cells are true? i. Cannot form T effector memory (TEM) T cell populations ii. Require the master transcription factor RORgammaT for their development iii. Produce effector cytokines IL-17 and IL-22 which help recruit neutrophils and stimulate antimicrobial peptide production iv. Do not require the transcription factor NFAT for IL-2 production downstream of TCR activation v. Important for defense against intracellular bacterial infection only a. i and iii b. ii and v c. ii and iii d. ii, iii, iv e. i, ii, and iv
Match the term with its correct description. Transcription factor required for T-cell development Composed of superdimer, CD3 and zeta chain Facilitates the expression of tissue-specific genes in thymic epithelium Selection for thymocytes which recognize self MHC molecules Elimination of thymocytes which recognize self ✓Choose... Negative selection Notch 1 Pre-T-cell receptor Positive selection AIRE Choose...
Which of the following statements pertain to this cell. This cell is a precursor to a cell which: 1. is an antigen-presenting cell 2. demonstrates MHC I molecules 3. demonstrates MHC II molecules 4. demonstrates CD4 molecules 5. is capable of synthesizing and releasing perforin and granzymes Choose from the following: (A) 1, 2, and 3 (B) 2 and 3 only (C) 3 and 4 only (D) 1 and 3 (E) 1, 4, and 5
Match the term with its correct description. Transcription factor required for T-cell development Composed of superdimer, CD3 and zeta chain Facilitates the expression of tissue-specific genes in thymic epithelium Selection for thymocytes which recognize self MHC molecules Elimination of thymocytes which recognize self ✓Choose... Negative selection Notch 1 Pre-T-cell receptor Positive selection AIRE Choose... ➡
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