Which of the following will result from the binding of one O₂ to a molecule of hemoglobin? the release of any other O₂ that may have bound earlier. a decrease in hemoglobin's affinity for CO2 an increase in hemoglobin's affinity for 2,3-bisphosphoglycerate. the movement of hemoglobin to an organism's muscle tissue. an increased affinity for O2 in the remaining subunits (which have not yet bound 0₂).
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- In addition to O2 binding, changes in other chemical conditions can result in changes in hemoglobin structure and function. Increases in blood H+ result in oxygen binding curves for hemoglobin that are shifted to the right. The effect of H+ can be understood in terms of the equilibrium:H-Hb+ + O2 → Hb-O2 + H+How does the difference in pH in the lungs and tissues help hemoglobin do its job of delivering oxygen? Use the equilibrium equation in your argument.Which of the following statements is correct of BOTH haemoglobin and myoglobin? Acidic conditions increase the affinity for oxygen. The iron atom of the heme prosthetic group is bound to nitrogen atoms at five of six coordination sites. Four oxygen molecules bind to each subunit. Quaternary structure is found in both haemoglobin and myoglobin. Both haemoglobin and myoglobin show the same oxygen binding affinity at differentCrocodiles can use virtually 100% of the oxygen in its blood, whereas humans can extract only about 65% of the oxygen in their blood. Crocodile hemoglobin (Hb) binds HCO3, rather than 2,3-bisphosphoglycerate (BPG), when in the T-state. Which of the following best explains why HCO3¯ in the crocodile works better than 2,3-BPG in humans to help the Hb to release more of its bound oxygen? Crocodile Hb binds more oxygen than human Hb, and so the crocodile has more oxygen available than humans do. The [HCO3] varies with the amount of oxygen used, whereas the [BPG] in human erythrocytes is constant regardless of need. Humans require their hemoglobin to be sensitive to [BPG] in order for HbF (fetal Hb) to have a higher affinity for oxygen than maternal Hb. Since crocodile Hb binds HCO3, the HCO3 will not be available to bind to H+ (Bohr protons), and so more oxygen will be released to the tissues. Crocodiles are cold-blooded and so do not need as much oxygen as humans; this is why they can…
- When the blood passes through the lungs, CO₂ is expelled and the hemoglobin picks up oxygen. Place the following steps in the correct order (1 = first thing to happen), assuming that it is the decreased [CO₂] during exhalation that initiates the transition. Carbonic anhydrase works to restore the CO₂/bicarbonate equilibrium, reducing the [H+] The T-state is less stabilized. Oxygen binds to the hemoglobin. Protons dissociate from the hemoglobin.To demonstrate an understanding of oxyhemoglobin binding, insert a word from the list in each blank to complete the statements. Not all terms will be used. increased A right shift of the oxy-hemoglobin curve signifies a affinity for oxygen. hold acidic A temperature will cause a right shift of the oxy- hemoglobin curve. basic A more pH than normal blood pH will cause a right shift higher of the oxy-hemoglobin curve. As a person exercises, their muscles give off heat which raises the temperature of the blood. This will cause hemoglobin to more oxygen at the cells. lower release decreasedThe transport and exchange of gases in the body is affected by the Bohr effect. Which of the following statements best describes the Bohr effect? The Bohr effect lowers the oxygen affinity of haemoglobin and is caused by an activity induced increase in pH in the active muscles. The Bohr effect lowers the oxygen affinity of haemoglobin facilitating its release in oxygen starved tissues. The Bohr effect facilitates oxygen transport to oxygen starved tissues as it increase’s the affinity of haemoglobin for oxygen. The Bohr effect lowers the oxygen affinity of haemoglobin resulting in a reduction in oxygen availability in the active muscles.
- Which of the following statements regarding the transport of oxygen by hemoglobin is correct? Upon binding of oxygen to heme, a shift in the position of the distal His ultimately induces the switch from T to R states When fully bound to oxygen, AG(R-state)The illustration below shows several oxygen-dissociation curves. Assume that curve 3 corresponds to hemoglobin with physiological concentrations of CO2 and 2,3-BPG at pH 7. Which curves represent each of the following perturbations? Saturation (Y) N P⁰₂ Loss of quaternary structure. Increase in 2,3-BPG Decrease in CO₂ 1. 1 2. 2 3. 3 4. 4Which of the following statements about oxygen transport is TRUE. Increases in temperature and decreases in pH cause myoglobin to release oxygen to improve delivery to the hemoglobin in muscles. A molecule of myoglobin has higher oxygen binding capacity than a molecule of hemoglobin. Myoglobin has a higher oxygen affinity than does hemoglobin. Fetal hemoglobin has a lower affinity for oxygen than maternal hemoglobin, which makes it better suited to extract oxygen from the maternal circulation.After spending a day or more at high altitude (with an oxygen partial pressure of 75 torr), the concentration of 2,3- bisphosphoglycerate (2,3-BPG) in red blood cells increases. What effect would an increased concentration of 2,3-BPG have on the oxygen-binding curve for hemoglobin? Why would this adaptation be beneficial for functioning well at high altitude?Carbon monoxide (CO) is a colourless, odourless gas that result from the burning of hydrocarbons, such as in a poorly functioning furnace or vehicle emissions. CO can bind with hemoglobin to form carboxyhemoglobin. Hemoglobin's affinity for CO is 200 times greater than its affinity for oxygen. The initial symptoms of carbon monoxide poisoning are flu-like, such as dizziness, headache and vomiting. However, when left unchecked, CO poisoning can result in unconsciousness, loss of blood flow to the vital organs and, eventually, death. (Source: Bleecker, M.L. (2015). Carbon Monoxide Intoxication. Handbook of Clinical Neurology. Elsevier B.V.) 5. Name the gases normally carried by hemoglobin in the body. Using your knowledge of the circulatory and respiratory systems, provide a possible explanation for the symptoms of carbon monoxide poisoning.Which of the following is incorrect about 2,3-bisphosphoglycerate (BPG)? It is highly (-) charged b. It prevents binding of O₂ to hemoglobin Oc. It binds only to the relaxed (oxy) conformation of hemoglobin Od. It binds in the space between the four subunits of hemoglobin a.SEE MORE QUESTIONS
